Kinetic discrimination in T-cell activation.
نویسندگان
چکیده
منابع مشابه
Kinetic discrimination in T-cell activation.
We propose a quantitative model for T-cell activation in which the rate of dissociation of ligand from T-cell receptors determines the agonist and antagonist properties of the ligand. The ligands are molecular complexes between antigenic peptides and proteins of the major histocompatibility complex on the surfaces of antigen-presenting cells. Binding of ligand to receptor triggers a series of b...
متن کاملFrom TCR Engagement to T Cell Activation A Kinetic View of T Cell Behavior
1998). While these studies represent a clear step forward in defining the requirements for aggregation in initiating TCR signaling, they still leave several open questions. The first model does not explain how a few complexes (say, less than 10) per APC might rapidly trigger T cells, while the second does not account for CD8-independent Switzerland responses. What is ultimately important is to ...
متن کاملB and T Lymphocyte Attenuator is a Target of miR-155 during Naive CD4+ T Cell Activation
Background: MicroRNA-155 (miR-155) is upregulated during T cell activation, but the exact mechanisms by which it influences CD4+ T cell activation remain unclear. Objective: To examine whether the B and T lymphocyte attenuator (BTLA) is a target of miR-155 during naïve CD4+ T cell activation. Methods: Firefly luciferase reporter plasmids pEZX-MT01-wild-type-BTLA and pEZX-MT01-mutant-BTLA were ...
متن کاملModelling T Cell Activation
The recognition of foreign antigen by T cells is the foundation of the adaptive immune response, and this has been demonstrated experimentally to be an extremely sensitive, specific and reliable process. In this thesis, models for T cell signalling based on recent experimental data are constructed to understand how these properties arise. The thesis first reviews the biological and mathematical...
متن کاملT-Cell Activation: Two for T
T-cell activation requires costimulation in addition to the antigen-specific signal. Recent results suggest that distinct costimulatory molecules can specifically activate different types of T-cell response.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.4.1401